|
Virus Diseases
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus.
|
12551893 |
2003 |
|
Vaso-Occlusive Crisis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The findings of elevated serum Fkn and Fkn gene expression in both vaso-occlusive crisis and stable forms of SCD suggest that this chemokine may be involved in the pathogenesis of inflammation observed in SCD.
|
25480631 |
2015 |
|
Vasculitis, Leukocytoclastic, Cutaneous
|
0.010 |
Biomarker
|
disease |
BEFREE |
To elucidate the role of CX3CL1 and CX3CR1 in the development of leukocytoclastic vasculitis, the cutaneous and peritoneal reverse Arthus reactions, classic experimental models for immune complex-mediated tissue injury, were examined in mice lacking CX3CR1.
|
23470165 |
2013 |
|
Vascular inflammations
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
On endothelial cells, the transmembrane chemokine CX3CL1/fractalkine promotes vascular inflammation by functioning as a surface-expressed adhesion molecule and by becoming released as soluble chemoattractant for monocytic cells expressing the receptor CX3CR1.
|
28522896 |
2017 |
|
Uveitis
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
The levels of all neutrophil chemoattractants and CXCL10, CXCL16, and CX3CL1 were significantly higher in nongranulomatous uveitis (Behçet's disease and HLA-B27-associated uveitis) than in granulomatous uveitis (sarcoidosis and VKH disease), whereas the levels of the B cell chemoattractant CXCL13 were significantly higher in granulomatous uveitis than in nongranulomatous uveitis.
|
29715366 |
2018 |
|
Uveitis
|
0.210 |
Biomarker
|
disease |
RGD |
Expression of fractalkine (CX3CL1) and its receptor in endotoxin-induced uveitis.
|
19648777 |
2009 |
|
Ulcerative Colitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Genotypes of fractalkine receptorc.745G>A (V249I) and c.839C>T (T280M) polymorphisms were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.Genotype distribution and allele frequencies of V249I and T280M were not statistically significantly different between UC and control groups (p>0.05).
|
26042517 |
2015 |
|
Ulcerative Colitis
|
0.030 |
Biomarker
|
disease |
BEFREE |
The chemokine fractalkine (CX3C chemokine ligand 1; CX3CL1) and its receptor CX3CR1 are involved in the pathogenesis of several diseases, including inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, rheumatoid arthritis, hepatitis, myositis, multiple sclerosis, renal ischemia, and atherosclerosis.
|
28842393 |
2017 |
|
Ulcerative Colitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Also, these cells expressed CX3CR1, which was related to the increased levels of intestinal FKN in UC patients, suggesting that a higher proportion of TLR2(+) mononuclear cells infiltrate the lamina propria.
|
22101184 |
2012 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, deletion of p16 <sup>Ink4</sup> and p21 <sup>Cip1/Waf1</sup> reduces CX3CR1 expression, thereby inhibiting Mo-MDSC accumulation in tumours expressing CX3CL1 and suppressing the tumour progression in mice.
|
29234059 |
2017 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
We provide initial evidence that CX3CL1 exposure resulted in EMT occurrence and enhancement of cell migration and invasion through a mechanism involving activation of TACE/TGF-α/EGFR signaling.
|
26718770 |
2016 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Therefore, CX3CL1 in spinal cancellous bone attracts CX3CR1-expressing tumor cells to the spine and enhances their migration and invasion abilities through the Src/FAK signaling pathway.
|
30310518 |
2018 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
CX3CL1 did not significantly affect H460 proliferation; however, CX3CL1 did significantly enhance the migration and invasion of H460 cells.
|
30628679 |
2019 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Luciferase assay was performed to evaluate the interaction between miR-485-5p and CX3CL1, the effects of miR-485-5p on MG-63 cells were determined by subsequent experiments including cell proliferation, expression level of CX3CL1, detection of invasion and migration capacities.
|
30468463 |
2018 |
|
Tuberculosis, extrapulmonary
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to know the prevalence of NTN among extrapulmonary tuberculosis cases in tertiary care centers in Northern India.
|
25883962 |
2015 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling.
|
24447880 |
2014 |
|
Systemic Scleroderma
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Increased serum fractalkine in systemic sclerosis. Down-regulation by prostaglandin E1.
|
18799080 |
2009 |
|
Systemic Scleroderma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CX3CL1 concentrations were increased in SSc in lung tissue as well as in sera.
|
30457999 |
2018 |
|
synovial sarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased serum levels of CX3CL1 protein were observed in SS patients compared with controls (P < 0.0001) and in RA patients compared with controls (P < 0.0001), but no difference was found between Sicca patients and controls (P = 0.22).
|
24324211 |
2014 |
|
Sweet Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased serum levels of CX3CL1 protein were observed in SS patients compared with controls (P < 0.0001) and in RA patients compared with controls (P < 0.0001), but no difference was found between Sicca patients and controls (P = 0.22).
|
24324211 |
2014 |
|
Streptozotocin Diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.
|
20388520 |
2010 |
|
Steroid Sulfatase Deficiency Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, this is the first study to show a significant correlation between combined low expression of CCL2 and CX3CL1 and a poor prognosis for STS patients, particularly in female patients.
|
24676787 |
2014 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among chemokines, we will highlight CCL2, CCL5, CXCL8-10, CX3CL1, and CXCL16 as pivotal mediators in the development of steatosis, NASH, and fibrosis.
|
29956205 |
2018 |
|
Status Epilepticus
|
0.200 |
Therapeutic
|
disease |
RGD |
The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus.
|
21481949 |
2011 |
|
Stable angina
|
0.020 |
Biomarker
|
disease |
BEFREE |
Transcoronary (TC) levels of chemokine ligand 2 (CCL2) and C-X3-C motif chemokine ligand 1 (CX3CL1) were significantly elevated in patients with ACS versus patients with SAP (P < 0.01).
|
31409556 |
2019 |